AustralieFrV1, Main, Exploration, bibRecord, 006A73

Genome-wide association study reveals three susceptibility loci for common migraine in the general population

Identifieur interne : 006A73 ( Main/Exploration ); précédent : 006A72; suivant : 006A74

Genome-wide association study reveals three susceptibility loci for common migraine in the general population

Auteurs : Daniel I. Chasman [États-Unis] ; Markus Schürks [États-Unis, Allemagne] ; Verneri Anttila [Royaume-Uni, Finlande] ; Boukje De Vries [Pays-Bas] ; Ulf Schminke [Allemagne] ; Lenore J. Launer [États-Unis] ; Gisela M. Terwindt [Pays-Bas] ; Arn M. J. M. Van Den Maagdenberg [Pays-Bas] ; Konstanze Fendrich [Allemagne] ; Henry Völzke [Allemagne] ; Florian Ernst [Allemagne] ; Lyn R. Griffiths [Australie] ; Julie E. Buring [États-Unis] ; Mikko Kallela [Finlande] ; Tobias Freilinger [Allemagne] ; Christian Kubisch [Allemagne] ; Paul M. Ridker [États-Unis] ; Aarno Palotie [Royaume-Uni, Finlande, États-Unis] ; Michel D. Ferrari [Pays-Bas] ; Wolfgang Hoffmann [Allemagne] ; Robert Y. L. Zee [États-Unis] ; Tobias Kurth [États-Unis, France]

Source :

Nature genetics [ 1061-4036 ] ; 2011.

RBID : Pascal:11-0339138

Descripteurs français

Pascal (Inist)
- Locus, Douleur, Migraine, Echelle du génome, Association génétique.

English descriptors

KwdEn :
- Locus, Migraine, Pain.

Abstract

Migraine is a common, heterogeneous and heritable neurological disorder. Its pathophysiology is incompletely understood, and its genetic influences at the population level are unknown. In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P < 5 × 10-⁶) with migraine. These SNPs were significant in a meta-analysis among three replication cohorts and met genome-wide significance in a meta-analysis combining the discovery and replication cohorts (rs2651899, odds ratio (OR) = 1.11, P = 3.8 x 10^-9; rs10166942, OR = 0.85, P = 5.5 × 10^-12; and rs11172113, OR = 0.90, P = 4.3 x 10^-9). The associations at rs2651899 and rs10166942 were specific for migraine compared with non-migraine headache. None of the three SNP associations was preferential for migraine with aura or without aura, nor were any associations specific for migraine features. TRPM8 has been the focus of neuropathic pain models, whereas LRP1 modulates neuronal glutamate signaling, plausibly linking both genes to migraine pathophysiology.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125402

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Genome-wide association study reveals three susceptibility loci for common migraine in the general population</title>
<author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Donald W. Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schurks, Markus" sort="Schurks, Markus" uniqKey="Schurks M" first="Markus" last="Schürks">Markus Schürks</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital Essen</s1>
<s2>Essen</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>University Hospital Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Anttila, Verneri" sort="Anttila, Verneri" uniqKey="Anttila V" first="Verneri" last="Anttila">Verneri Anttila</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Wellcome Trust Sanger Institute</s1>
<s2>Hinxton, Cambridge</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Wellcome Trust Sanger Institute</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>3 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
</author>
<author><name sortKey="De Vries, Boukje" sort="De Vries, Boukje" uniqKey="De Vries B" first="Boukje" last="De Vries">Boukje De Vries</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Human Genetics, Leiden University Medical Centre</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schminke, Ulf" sort="Schminke, Ulf" uniqKey="Schminke U" first="Ulf" last="Schminke">Ulf Schminke</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, Ernst-Moritz-Arndt University</s1>
<s2>Greifswald</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Ernst-Moritz-Arndt University</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="2"><inist:fA14 i1="08"><s1>National Institute of Aging, Laboratory for Epidemiology, Demography, and Biometry</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Terwindt, Gisela M" sort="Terwindt, Gisela M" uniqKey="Terwindt G" first="Gisela M." last="Terwindt">Gisela M. Terwindt</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Neurology, Leiden University Medical Centre</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Den Maagdenberg, Arn M J M" sort="Van Den Maagdenberg, Arn M J M" uniqKey="Van Den Maagdenberg A" first="Arn M. J. M." last="Van Den Maagdenberg">Arn M. J. M. Van Den Maagdenberg</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Human Genetics, Leiden University Medical Centre</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Neurology, Leiden University Medical Centre</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fendrich, Konstanze" sort="Fendrich, Konstanze" uniqKey="Fendrich K" first="Konstanze" last="Fendrich">Konstanze Fendrich</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Institute for Community Medicine, Section Epidemiology of Health Care and Community Health, Ernst-Moritz-Arndt University</s1>
<s2>Greifswald</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Ernst-Moritz-Arndt University</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Institute for Community Medicine, Section Clinical Epidemiological Research, Ernst-Moritz-Arndt University</s1>
<s2>Greifswald</s2>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Ernst-Moritz-Arndt University</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt University</s1>
<s2>Greifswald</s2>
<s3>DEU</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Ernst-Moritz-Arndt University</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Griffiths, Lyn R" sort="Griffiths, Lyn R" uniqKey="Griffiths L" first="Lyn R." last="Griffiths">Lyn R. Griffiths</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Genomics Research Centre, Griffith Health Institute, Griffith University</s1>
<s2>Gold Coast, Queensland</s2>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Gold Coast, Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E." last="Buring">Julie E. Buring</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kallela, Mikko" sort="Kallela, Mikko" uniqKey="Kallela M" first="Mikko" last="Kallela">Mikko Kallela</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, Helsinki University Central Hospital</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Freilinger, Tobias" sort="Freilinger, Tobias" uniqKey="Freilinger T" first="Tobias" last="Freilinger">Tobias Freilinger</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-Universität and Institute for Stroke and Dementia Research, Klinikum der Unlversität München</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kubisch, Christian" sort="Kubisch, Christian" uniqKey="Kubisch C" first="Christian" last="Kubisch">Christian Kubisch</name>
<affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Institute of Human Genetics, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Donald W. Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Wellcome Trust Sanger Institute</s1>
<s2>Hinxton, Cambridge</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Wellcome Trust Sanger Institute</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>3 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="17"><s1>Department of Medical Genetics, University of Helsinki</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Medical Genetics, Helsinki University Central Hospital</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="19"><s1>The Broad Institute of MIT and Harvard</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ferrari, Michel D" sort="Ferrari, Michel D" uniqKey="Ferrari M" first="Michel D." last="Ferrari">Michel D. Ferrari</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Neurology, Leiden University Medical Centre</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoffmann, Wolfgang" sort="Hoffmann, Wolfgang" uniqKey="Hoffmann W" first="Wolfgang" last="Hoffmann">Wolfgang Hoffmann</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Institute for Community Medicine, Section Epidemiology of Health Care and Community Health, Ernst-Moritz-Arndt University</s1>
<s2>Greifswald</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Ernst-Moritz-Arndt University</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zee, Robert Y L" sort="Zee, Robert Y L" uniqKey="Zee R" first="Robert Y. L." last="Zee">Robert Y. L. Zee</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kurth, Tobias" sort="Kurth, Tobias" uniqKey="Kurth T" first="Tobias" last="Kurth">Tobias Kurth</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="20"><s1>INSERM Unit 708-Neuroepidemiology</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>UPMC Univ Paris 06</s1>
<s2>75005, Paris</s2>
<s3>FRA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">11-0339138</idno>
<date when="2011">2011</date>
<idno type="stanalyst">PASCAL 11-0339138 INIST</idno>
<idno type="RBID">Pascal:11-0339138</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001A84</idno>
<idno type="wicri:Area/PascalFrancis/Curation">004460</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001A63</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001A63</idno>
<idno type="wicri:doubleKey">1061-4036:2011:Chasman D:genome:wide:association</idno>
<idno type="wicri:Area/Main/Merge">006F14</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125402</idno>
<idno type="RBID">PMC:3125402</idno>
<idno type="wicri:Area/Pmc/Corpus">001558</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001558</idno>
<idno type="wicri:Area/Pmc/Curation">001418</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001418</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002306</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002306</idno>
<idno type="wicri:Area/Ncbi/Merge">000A90</idno>
<idno type="wicri:Area/Ncbi/Curation">000A90</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000A90</idno>
<idno type="wicri:doubleKey">1061-4036:2011:Chasman D:genome:wide:association</idno>
<idno type="wicri:Area/Main/Merge">006502</idno>
<idno type="wicri:Area/Main/Curation">006A73</idno>
<idno type="wicri:Area/Main/Exploration">006A73</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Genome-wide association study reveals three susceptibility loci for common migraine in the general population</title>
<author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Donald W. Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schurks, Markus" sort="Schurks, Markus" uniqKey="Schurks M" first="Markus" last="Schürks">Markus Schürks</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University Hospital Essen</s1>
<s2>Essen</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>University Hospital Essen</wicri:noRegion>
<wicri:noRegion>Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Anttila, Verneri" sort="Anttila, Verneri" uniqKey="Anttila V" first="Verneri" last="Anttila">Verneri Anttila</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Wellcome Trust Sanger Institute</s1>
<s2>Hinxton, Cambridge</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Wellcome Trust Sanger Institute</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>3 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
</author>
<author><name sortKey="De Vries, Boukje" sort="De Vries, Boukje" uniqKey="De Vries B" first="Boukje" last="De Vries">Boukje De Vries</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Human Genetics, Leiden University Medical Centre</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schminke, Ulf" sort="Schminke, Ulf" uniqKey="Schminke U" first="Ulf" last="Schminke">Ulf Schminke</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, Ernst-Moritz-Arndt University</s1>
<s2>Greifswald</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Ernst-Moritz-Arndt University</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="2"><inist:fA14 i1="08"><s1>National Institute of Aging, Laboratory for Epidemiology, Demography, and Biometry</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Terwindt, Gisela M" sort="Terwindt, Gisela M" uniqKey="Terwindt G" first="Gisela M." last="Terwindt">Gisela M. Terwindt</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Neurology, Leiden University Medical Centre</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Den Maagdenberg, Arn M J M" sort="Van Den Maagdenberg, Arn M J M" uniqKey="Van Den Maagdenberg A" first="Arn M. J. M." last="Van Den Maagdenberg">Arn M. J. M. Van Den Maagdenberg</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Human Genetics, Leiden University Medical Centre</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Neurology, Leiden University Medical Centre</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fendrich, Konstanze" sort="Fendrich, Konstanze" uniqKey="Fendrich K" first="Konstanze" last="Fendrich">Konstanze Fendrich</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Institute for Community Medicine, Section Epidemiology of Health Care and Community Health, Ernst-Moritz-Arndt University</s1>
<s2>Greifswald</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Ernst-Moritz-Arndt University</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Institute for Community Medicine, Section Clinical Epidemiological Research, Ernst-Moritz-Arndt University</s1>
<s2>Greifswald</s2>
<s3>DEU</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Ernst-Moritz-Arndt University</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt University</s1>
<s2>Greifswald</s2>
<s3>DEU</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Ernst-Moritz-Arndt University</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Griffiths, Lyn R" sort="Griffiths, Lyn R" uniqKey="Griffiths L" first="Lyn R." last="Griffiths">Lyn R. Griffiths</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Genomics Research Centre, Griffith Health Institute, Griffith University</s1>
<s2>Gold Coast, Queensland</s2>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Gold Coast, Queensland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E." last="Buring">Julie E. Buring</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kallela, Mikko" sort="Kallela, Mikko" uniqKey="Kallela M" first="Mikko" last="Kallela">Mikko Kallela</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, Helsinki University Central Hospital</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Freilinger, Tobias" sort="Freilinger, Tobias" uniqKey="Freilinger T" first="Tobias" last="Freilinger">Tobias Freilinger</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-Universität and Institute for Stroke and Dementia Research, Klinikum der Unlversität München</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kubisch, Christian" sort="Kubisch, Christian" uniqKey="Kubisch C" first="Christian" last="Kubisch">Christian Kubisch</name>
<affiliation wicri:level="4"><inist:fA14 i1="16"><s1>Institute of Human Genetics, University of Ulm</s1>
<s2>Ulm</s2>
<s3>DEU</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Donald W. Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Wellcome Trust Sanger Institute</s1>
<s2>Hinxton, Cambridge</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Wellcome Trust Sanger Institute</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Institute for Molecular Medicine Finland (FIMM), University of Helsinki</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>3 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="17"><s1>Department of Medical Genetics, University of Helsinki</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<placeName><settlement type="city">Helsinki</settlement>
<region type="région" nuts="2">Uusimaa</region>
</placeName>
<orgName type="university">Université d'Helsinki</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Medical Genetics, Helsinki University Central Hospital</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="19"><s1>The Broad Institute of MIT and Harvard</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ferrari, Michel D" sort="Ferrari, Michel D" uniqKey="Ferrari M" first="Michel D." last="Ferrari">Michel D. Ferrari</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Neurology, Leiden University Medical Centre</s1>
<s2>Leiden</s2>
<s3>NLD</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoffmann, Wolfgang" sort="Hoffmann, Wolfgang" uniqKey="Hoffmann W" first="Wolfgang" last="Hoffmann">Wolfgang Hoffmann</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Institute for Community Medicine, Section Epidemiology of Health Care and Community Health, Ernst-Moritz-Arndt University</s1>
<s2>Greifswald</s2>
<s3>DEU</s3>
<sZ>9 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Greifswald</wicri:noRegion>
<wicri:noRegion>Ernst-Moritz-Arndt University</wicri:noRegion>
<wicri:noRegion>Greifswald</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zee, Robert Y L" sort="Zee, Robert Y L" uniqKey="Zee R" first="Robert Y. L." last="Zee">Robert Y. L. Zee</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kurth, Tobias" sort="Kurth, Tobias" uniqKey="Kurth T" first="Tobias" last="Kurth">Tobias Kurth</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="20"><s1>INSERM Unit 708-Neuroepidemiology</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>UPMC Univ Paris 06</s1>
<s2>75005, Paris</s2>
<s3>FRA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Locus</term>
<term>Migraine</term>
<term>Pain</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Locus</term>
<term>Douleur</term>
<term>Migraine</term>
<term>Echelle du génome</term>
<term>Association génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Migraine is a common, heterogeneous and heritable neurological disorder. Its pathophysiology is incompletely understood, and its genetic influences at the population level are unknown. In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P < 5 × 10-<sup>6</sup>
) with migraine. These SNPs were significant in a meta-analysis among three replication cohorts and met genome-wide significance in a meta-analysis combining the discovery and replication cohorts (rs2651899, odds ratio (OR) = 1.11, P = 3.8 x 10<sup>-9</sup>
; rs10166942, OR = 0.85, P = 5.5 × 10<sup>-12</sup>
; and rs11172113, OR = 0.90, P = 4.3 x 10<sup>-9</sup>
). The associations at rs2651899 and rs10166942 were specific for migraine compared with non-migraine headache. None of the three SNP associations was preferential for migraine with aura or without aura, nor were any associations specific for migraine features. TRPM8 has been the focus of neuropathic pain models, whereas LRP1 modulates neuronal glutamate signaling, plausibly linking both genes to migraine pathophysiology.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Finlande</li>
<li>France</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>Bavière</li>
<li>District de Haute-Bavière</li>
<li>District de Tübingen</li>
<li>Hollande-Méridionale</li>
<li>Maryland</li>
<li>Massachusetts</li>
<li>Uusimaa</li>
<li>Île-de-France</li>
</region>
<settlement><li>Helsinki</li>
<li>Leyde</li>
<li>Munich</li>
<li>Paris</li>
<li>Ulm</li>
</settlement>
<orgName><li>Université d'Helsinki</li>
<li>Université d'Ulm</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name>
</region>
<name sortKey="Buring, Julie E" sort="Buring, Julie E" uniqKey="Buring J" first="Julie E." last="Buring">Julie E. Buring</name>
<name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name>
<name sortKey="Kurth, Tobias" sort="Kurth, Tobias" uniqKey="Kurth T" first="Tobias" last="Kurth">Tobias Kurth</name>
<name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name>
<name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M." last="Ridker">Paul M. Ridker</name>
<name sortKey="Schurks, Markus" sort="Schurks, Markus" uniqKey="Schurks M" first="Markus" last="Schürks">Markus Schürks</name>
<name sortKey="Zee, Robert Y L" sort="Zee, Robert Y L" uniqKey="Zee R" first="Robert Y. L." last="Zee">Robert Y. L. Zee</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Schurks, Markus" sort="Schurks, Markus" uniqKey="Schurks M" first="Markus" last="Schürks">Markus Schürks</name>
</noRegion>
<name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name>
<name sortKey="Fendrich, Konstanze" sort="Fendrich, Konstanze" uniqKey="Fendrich K" first="Konstanze" last="Fendrich">Konstanze Fendrich</name>
<name sortKey="Freilinger, Tobias" sort="Freilinger, Tobias" uniqKey="Freilinger T" first="Tobias" last="Freilinger">Tobias Freilinger</name>
<name sortKey="Hoffmann, Wolfgang" sort="Hoffmann, Wolfgang" uniqKey="Hoffmann W" first="Wolfgang" last="Hoffmann">Wolfgang Hoffmann</name>
<name sortKey="Kubisch, Christian" sort="Kubisch, Christian" uniqKey="Kubisch C" first="Christian" last="Kubisch">Christian Kubisch</name>
<name sortKey="Schminke, Ulf" sort="Schminke, Ulf" uniqKey="Schminke U" first="Ulf" last="Schminke">Ulf Schminke</name>
<name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Anttila, Verneri" sort="Anttila, Verneri" uniqKey="Anttila V" first="Verneri" last="Anttila">Verneri Anttila</name>
</noRegion>
<name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
</country>
<country name="Finlande"><region name="Uusimaa"><name sortKey="Anttila, Verneri" sort="Anttila, Verneri" uniqKey="Anttila V" first="Verneri" last="Anttila">Verneri Anttila</name>
</region>
<name sortKey="Kallela, Mikko" sort="Kallela, Mikko" uniqKey="Kallela M" first="Mikko" last="Kallela">Mikko Kallela</name>
<name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
<name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="De Vries, Boukje" sort="De Vries, Boukje" uniqKey="De Vries B" first="Boukje" last="De Vries">Boukje De Vries</name>
</region>
<name sortKey="Ferrari, Michel D" sort="Ferrari, Michel D" uniqKey="Ferrari M" first="Michel D." last="Ferrari">Michel D. Ferrari</name>
<name sortKey="Terwindt, Gisela M" sort="Terwindt, Gisela M" uniqKey="Terwindt G" first="Gisela M." last="Terwindt">Gisela M. Terwindt</name>
<name sortKey="Van Den Maagdenberg, Arn M J M" sort="Van Den Maagdenberg, Arn M J M" uniqKey="Van Den Maagdenberg A" first="Arn M. J. M." last="Van Den Maagdenberg">Arn M. J. M. Van Den Maagdenberg</name>
<name sortKey="Van Den Maagdenberg, Arn M J M" sort="Van Den Maagdenberg, Arn M J M" uniqKey="Van Den Maagdenberg A" first="Arn M. J. M." last="Van Den Maagdenberg">Arn M. J. M. Van Den Maagdenberg</name>
</country>
<country name="Australie"><noRegion><name sortKey="Griffiths, Lyn R" sort="Griffiths, Lyn R" uniqKey="Griffiths L" first="Lyn R." last="Griffiths">Lyn R. Griffiths</name>
</noRegion>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Kurth, Tobias" sort="Kurth, Tobias" uniqKey="Kurth T" first="Tobias" last="Kurth">Tobias Kurth</name>
</region>
<name sortKey="Kurth, Tobias" sort="Kurth, Tobias" uniqKey="Kurth T" first="Tobias" last="Kurth">Tobias Kurth</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006A73 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 006A73 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:11-0339138
   |texte=   Genome-wide association study reveals three susceptibility loci for common migraine in the general population
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Genome-wide association study reveals three susceptibility loci for common migraine in the general population

Genome-wide association study reveals three susceptibility loci for common migraine in the general population

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.